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A Potential Nanomedicine Consisting of Heparin-Loaded Polysaccharide Nanocarriers for the Treatment of Asthma

✍ Scribed by Felipe A. Oyarzun-Ampuero; Jose Brea; Maria I. Loza; Maria J. Alonso; Dolores Torres

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
392 KB
Volume
12
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

A new nanomedicine consisting of chitosan/carboxymethyl‐β‐cyclodextrin loaded with unfractioned or low‐molecular‐weight heparin is described and its potential in asthma treatment is evaluated. The nanoparticles are prepared by ionotropic gelation showing a size that between 221 and 729 nm with a positive zeta potential. The drug association efficiency is higher than 70%. Developed nanosystems are stable in Hank's balanced salt solution at pH = 6.4, releasing the drug slowly. Ex vivo assays show that nanocarriers lead to an improvement of heparin preventing mast cell degranulation. These results agree with the effective cellular internalization of the fluorescently labeled nanocarriers, and suggest these nanomedicines as promising formulations for asthma treatment.magnified image

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