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A postoligomerization synthesis of oligodeoxynucleotides containing polycyclic aromatic hydrocarbon adducts at the N6 position of deoxyadenosine.

โœ Scribed by Kim, Seong Jin; Stone, Michael P.; Harris, Constance M.; Harris, Thomas M.


Book ID
126063341
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
251 KB
Volume
114
Category
Article
ISSN
0002-7863

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The exocyclic amino groups of deoxyadenosine and deoxyguanosine readily add to C-10 of the benzo[a]pyrene 7,8-diol 9,10-epoxides at room temperature overnight in trifluoroethanol. Whereas the dG adducts are obtained as a mixture of cis-and trans-opened diastereomers, the dA adducts arise exclusively