A possible transition state assembly for highly diastereoselective conjugate addition reactions of lithium dimethylcuprate with α,β-enones

✍ Scribed by E.J Corey; Francis J Hannon

• Book ID: 104222082
• Publisher: Elsevier Science
• Year: 1990
• Tongue: French
• Weight: 269 KB
• Volume: 31
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)88814-0

✦ Synopsis

A transition state assembly is proposed for the l&addition of lithium dimethylcuprate to a$unsaturated ketones which provides general agreement with experimental observations of high stereoselectivity for substrates such as chiral al-substituted a$-enones, Ssubstituted 2-cyclohexenones, medium ring a$-enones, and At&ctalin-Zones.