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A possible gene silencing mechanism: Hypermethylation of the Keap1 promoter abrogates binding of the transcription factor Sp1 in lung cancer cells

โœ Scribed by Duo Guo; Bo Wu; Jihong Yan; Xiaoshuang Li; Haimei Sun; Deshan Zhou

Book ID
119194683
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
484 KB
Volume
428
Category
Article
ISSN
0006-291X

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## Abstract The transcription factor Sp1 plays an important regulatory role in transactivation of the lung type I cell differentiation gene __T1ฮฑ__. Like other lung cells, type I cells may encounter changes in oxygen concentration during the lifetime of the organism. We found that exposure of mice