𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A possible correlation between the degree of karyotype aberrations and the rate of sister chromatid exchanges in lymphoma lines

✍ Scribed by Christa Fonatsch; Michael Schaadt; Hartmut Kirchner; Volker Diehl

Publisher
John Wiley and Sons
Year
1980
Tongue
French
Weight
611 KB
Volume
26
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The sister chromatid exchange (SCE) frequencies of six freshly established and two old cell lines derived from patients with lymphatic tumors or leukemia were compared to the SCE rates of lymphoblastoid cell lines of normal controls. All cell lines from malignant tumors displayed significantly higher SCE values than the control lines. In general, the SCE rates seem to be correlated to the number of chromosomal markers and the degree of karyotypic instability of each line.

πŸ“œ SIMILAR VOLUMES

The rate of sister chromatid exchanges p
The rate of sister chromatid exchanges parallel to spontaneous chromosome breakage in Fanconi's anemia and to trenimon-induced aberrations in human lymphocytes and fibroblasts
✍ K. Hayashi; W. Schmid πŸ“‚ Article πŸ“… 1975 πŸ› Springer 🌐 English βš– 356 KB

The incidence of structural chromosome aberrations and the rate of sister chromatid exchanges (SCE) was investigated in lymphocyte cultures from a patient with typical Fanconi's anemia and his parents. The rate of SCEs was found to be normal. In experiments with the alkylating agent Trenimon the SCE