A Possible Anti-folic Acid Effect of Urethane
β Scribed by LEE, K. Y.; SHUBIK, PHILIPPE
- Book ID
- 109643073
- Publisher
- Nature Publishing Group
- Year
- 1965
- Tongue
- English
- Weight
- 271 KB
- Volume
- 206
- Category
- Article
- ISSN
- 0028-0836
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## Abstract Uptake of folic acid was measured in secondary cultures of skin fibroblasts from fetal rats. The cultures were made quiescent by 24 hours preincubation in medium containing 1% serum and subsequent 3 hours preincubation in phosphate buffered saline. The uptake of ^3^Hβfolic acid was line
OLIC ACID administered to mice 1 hour be-F fore a lethal dose of aminopterin prevents death due to the drug.8 A nonlethal "priming" dose (LD,) of aminopterin abolishes this protective effect.' Simultaneous administration of folinic acid (5-formyl-5,6,7,8-tetrahydropteroylglutamic acid) also protects