𝔖 Bobbio Scriptorium
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A positive cross-regulation of HER2 and ER-α36 controls ALDH1 positive breast cancer cells

✍ Scribed by Lianguo Kang; Yuming Guo; Xintian Zhang; Jun Meng; Zhao-Yi Wang

Book ID
116698722
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
661 KB
Volume
127
Category
Article
ISSN
0960-0760

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✍ Józefa Węsierska-Gądek; David Gritsch; Nora Zulehner; Oxana Komina; Margarita Ma 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 379 KB

## Abstract Roscovitine (ROSC), a selective cyclin‐dependent kinase (CDK) inhibitor, arrests human estrogen receptor‐α (ER‐α) positive MCF‐7 breast cancer cells in the G~2~ phase of the cell cycle and concomitantly induces apoptosis __via__ a p53‐dependent pathway. The effect of ROSC is markedly di