✦ LIBER ✦

A population-based family study (II): Segregation analysis

✍ Scribed by L.P. Zhao; F. Quiaoit; L. Hsu; O. Davidov; S. Holte

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 33 KB
Volume: 14
Category: Article
ISSN: 0741-0395
DOI: 10.1002/(sici)1098-2272(1997)14:6<945::aid-gepi64>3.0.co;2-l

No coin nor oath required. For personal study only.

✦ Synopsis

We used segregation analysis to investigate the genetic etiology of the disease in Problem 2A. Under the assumption of a dominant major gene, our analysis suggests a major gene with relative risk of 58 and an allele frequency of 0.013. Under an additive gene assumption, it appears that there may be two genes with relative risks of 39 and 17 and allele frequencies of 0.015 and 0.075, respectively.

📜 SIMILAR VOLUMES

A population-based family study of minor

A population-based family study of minor depression

✍ Stephen C. Newman; Roger C. Bland 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 75 KB

Gibbs sampling–based segregation analysi

Gibbs sampling–based segregation analysis of asthma-associated quantitative traits in a population-based sample of nuclear families

✍ Lyle J. Palmer; William O.C.M. Cookson; Alan L. James; A. William Musk; Paul R. 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 102 KB

Asthma is a common, complex human disease. Elevated serum immunoglobulin E (IgE) levels, elevated blood eosinophil counts, and increased airway responsiveness are physiological traits that are characteristic of asthma. Few studies have investigated major gene effects for these traits in a population

Prostate cancer segregation analyses usi

Prostate cancer segregation analyses using 4390 families from UK and Australian population-based studies

✍ Robert J. MacInnis; Antonis C. Antoniou; Rosalind A. Eeles; Gianluca Severi; Mic 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 120 KB

## Abstract Familial aggregation of prostate cancer is likely to be due to multiple susceptibility loci, perhaps acting in conjunction with shared lifestyle risk factors. Models that assume a single mode of inheritance may be unrealistic. We analyzed genetic models of susceptibility to prostate can

Familial risk of migraine: A population-

Familial risk of migraine: A population-based study

✍ Dr Walter F. Stewart; Judy Staffa; Richard B. Lipton; Ruth Ottman 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 659 KB

Inclusion of risk factor covariates in a

Inclusion of risk factor covariates in a segregation analysis of a population-based sample of 426 breast cancer families

✍ Dawn M. Grabrick; V. Elving Anderson; Richard A. King; Lawrence H. Kushi; Thomas 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 72 KB 👁 2 views

Although many segregation analyses of breast cancer have been published, few have included risk factor covariates. Maximum likelihood segregation analyses examining age-at-onset (model 1) and susceptibility (model 2) models of breast cancer were performed on 426 four-generation families originally a

A population based family study of a com

A population based family study of a common oligogenic disease — part I: Association/aggregation analysis

✍ Sarah Holte; Filemon Quiaoit; Li Hsu; Ori Davidov; Lue Ping Zhao 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 26 KB 👁 2 views

demonstrate the association/aggregation analysis of case-control family data, which is described as part of the population-based family study design described in Zhao et al.