A polyphosphoric acid-catalyzed spiroamidation. The conversion of N-[3-(1-cyclohexen-1-yl)propyl]-2-(3,4-dimethoxyphenyl)acetamide to 1-veratrylcarbonyl-1-azaspiro[4.5]decane
✍ Scribed by Raymond R. Wittekind; Carl Weissman; Sheldon Farber; Robert I. Meltzer
- Book ID
- 112121566
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1967
- Tongue
- English
- Weight
- 290 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0022-152X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Cyclization of ethyl (__E__)/(__Z__)‐[2‐(1‐cyclohexen‐1‐yl)cyclohexylidene]cyanoacetate (2) in cold concentrated sulfuric acid affords 10‐amino‐1,2,3,4,5,6,7,8‐octahydrophenanthrene‐9‐carboxylic acid (4) and 3,5,6,7,8,8a‐hexahydro‐3‐oxospiro‐[1__H__‐2‐benzopyran‐1,1′‐cyclohexane]‐4‐carb
## Abstract Although fenofibrate (**1a**) is commercially available and clinically effective in lowering serum triglycerides, its activity and sub‐type selectivity at the PPARα receptors are only moderate; therefore, there exists a need for more potent and sub‐type selective PPARα agonists. To that