A polypeptide growth inhibitor isolated from lactating bovine mammary gland (MDGI) is a lipid-carrying protein
✍ Scribed by Frank-D. Böhmer; Maren Mieth; Gunter Reichmann; Christel Taube; Richard Grosse; Morley D. Hollenberg
- Book ID
- 102303153
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 379 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0730-2312
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✦ Synopsis
Mammary-derived growth inhibitor (MDGI), a polypeptide growth inhibitor isolated from lactating bovine mammary tissue, previously shown to have extensive sequence homology with fatty acid-binding proteins, was demonstrated to meet the criteria of a fatty acid-binding protein. The protein was found to bind [3H]palmitic acid in a saturable manner and to be complexed with endogeneous free fatty acids. [3H]palmitic acid, when bound to the protein, was more rapidly taken up by the target cells (human mammary carcinoma cells [MaTu]) than was free [3H]palmitic acid, suggesting a lipid carrier function for the inhibitor. It is suggested that the fatty acid-binding properties of MDGI may relate to its ability to inhibit cell growth in vitro and to regulate other cellular functions.