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A polymorphism in the G protein β3-subunit gene is associated with bone metastasis risk in breast cancer patients

✍ Scribed by H. Clar; U. Langsenlehner; P. Krippl; W. Renner; A. Leithner; G. Gruber; G. Hofmann; B. Yazdani-Biuki; T. Langsenlehner; R. Windhager


Publisher
Springer US
Year
2007
Tongue
English
Weight
158 KB
Volume
111
Category
Article
ISSN
0167-6806

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CYP17 encodes the enzyme cytochrome P-450c17␣, which mediates both 17␣-hydroxylase and 17,20-lyase in the steroid biosynthesis pathway. A polymorphism in the 5 promoter region of the CYP17 gene has been described. Steroid hormones, especially androgens, are believed to play a key role in the etiolog