The 3' portion of the coagulation factor VII gene, containing the activation and serine protease domains, was investigated in four subjects with factor VII deficiency by temperature gradient gel electrophoresis and sequencing of polymerase chain reaction (PCR) products. Molecules displaying an alter
A polymorphism in the 5′ region of coagulation factor VII gene (F7) caused by an inserted decanucleotide
✍ Scribed by G. Marchetti; P. Patracchini; M. Papacchini; M. Ferrati; F. Bernardi
- Publisher
- Springer
- Year
- 1993
- Tongue
- English
- Weight
- 230 KB
- Volume
- 90
- Category
- Article
- ISSN
- 0340-6717
No coin nor oath required. For personal study only.
✦ Synopsis
We describe a polymorphism in the 5' region of the coagulation factor VII (FVII) gene, originating from a decanucleotide (CCTATATCCT) insert present in the less frequent allele. This marker can be detected by restriction analysis of polymerase chain reaction products.
📜 SIMILAR VOLUMES
Polymorphic variants in the gene encoding factor VII (F7) affect the plasma levels of this coagulation protein and modify the clinical phenotype of FVII deficiency in some patients. In this study we report the in vitro functional analysis of a novel polymorphic variant located in the 3 0 untranslate