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A polymorphism in metallothionein 1A (MT1A) is associated with cadmium-related excretion of urinary beta 2‐microglobulin

✍ Scribed by Lijian Lei; Xiuli Chang; Gerda Rentschler; Liting Tian; Guoying Zhu; Xiao Chen; Taiyi Jin; Karin Broberg

Book ID: 119374900
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 945 KB
Volume: 265
Category: Article
ISSN: 0041-008X
DOI: 10.1016/j.taap.2012.09.006

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## Abstract Membrane‐type metalloproteinase‐1 (MT1‐MMP) is a transmembrane metalloproteinase overexpressed in tumors, which plays a major role in the first step of pro‐MMP‐2 activation, leading to the generation of an intermediate 62 kDa species. The second step of MMP‐2 activation that yields to t