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A polymorphism at the miR-502 binding site in the 3′-untranslated region of the histone methyltransferase SET8 is associated with hepatocellular carcinoma outcome

✍ Scribed by Zhanjun Guo; Chensi Wu; Xiaoling Wang; Cuiju Wang; Ruixing Zhang; Baoen Shan

Book ID: 112101675
Publisher: John Wiley and Sons
Year: 2012
Tongue: French
Weight: 446 KB
Volume: 131
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.27352

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## Abstract The miR‐34 family members are direct transcriptional targets of tumor suppressor p53, and loss of miR‐34 function can impair p53‐mediated cell cycle arrest and apoptosis. A potentially functional SNP rs4938723 (T > C) was found in the promoter region of __pri‐miR‐34b/c__ (423 bp from th