A polymorphicCfoI site in exon 6 of the human cytochrome P450 CYP2D6 gene detected by the polymerase chain reaction
โ Scribed by Martin Armstrong; Jeffrey R. Idle; Ann K. Daly
- Publisher
- Springer
- Year
- 1993
- Tongue
- English
- Weight
- 109 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0340-6717
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๐ SIMILAR VOLUMES
A novel mutation that generates a stop codon in the third exon of the gene encoding the cytochrome P-450 CYP2D6 was identified in a Caucasian having a deficiency of the isozyme, by means of single strand conformation polymorphism analysis of DNA fragments amplified by the polymerase chain reaction,
A cDNA clone encoding a cytochrome P450 from H. armigera was used to examine the expression of two homologous cytochrome P450 mRNAs, one of which, CYP6B2, is probably involved in pyrethroid metabolism. The mRNA for CYP6B2 in particular can be induced up to tenfold by peppermint oil and the monoterpe