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A polymorphic variant at the Werner helicase (WRN) gene is associated with bone density, but not spondylosis, in postmenopausal women

✍ Scribed by Naoshi Ogata; Masataka Shiraki; Takayuki Hosoi; Yu Koshizuka; Kozo Nakamura; Hiroshi Kawaguchi


Publisher
Springer
Year
2001
Tongue
English
Weight
163 KB
Volume
19
Category
Article
ISSN
0914-8779

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We examined the association of bone mineral density (BMD) with a polymorphism in the gene encoding the vitamin D receptor (VOR) that causes a change in the predicted protein sequence. The polymorphism results from a C-to-T transition and creates an initiation codon (ATG) three codons proximal to a d