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A polymeric reagent for peptide synthesis: O-hydroxynitrophenyl derivative of polystyrene

โœ Scribed by Govind T. Panse; Daniel A. Laufer


Publisher
Elsevier Science
Year
1970
Tongue
French
Weight
232 KB
Volume
11
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


It is known that the stepwise coupling of amino acids (eq 1) may be accelerated to com-

pletion by the use of excess molar quantities of either R-CO-X or R'-NH2. The desired product may be isolated by filtration or centrifugation if either reagent is an insoluble polymer (eqs 2,3). Reaction 2 corresponds to the well known Merrifield solid phase method.'


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