A polygenic model with common variants may predict lung adenocarcinoma risk in humans

✍ Scribed by Antonella Galvan; Felicia S. Falvella; Monica Spinola; Elisa Frullanti; Vera P. Leoni; Sara Noci; Maria R. Alonso; Anna Zolin; Elena Spada; Silvano Milani; Ugo Pastorino; Matteo Incarbone; Luigi Santambrogio; Anna Gonzalez Neira; Tommaso A. Dragani

• Book ID: 102270316
• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: French
• Weight: 131 KB
• Volume: 123
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.23789

✦ Synopsis

Abstract

Genome‐wide screening for genetic loci associated with risk of lung adenocarcinoma (ADCA) was carried out in pooled DNA using the Illumina 300K single‐nucleotide polymorphism (SNP) array, in a joint analysis of 2 Italian case–control series matched by age, gender and smoking habit. The rare allele carrier status of 8 SNPs was associated with a decreased lung ADCA risk [odds ratios (OR): 0.6–0.8]. In a polygenic model characterized by additive and interchangeable effects, individuals carrying 2 to 6 rare alleles at these 8 SNPs showed a significant trend toward a decreased risk of lung ADCA (up to OR of 0.3). These results suggest the relevance of a polygenic model in the modulation of individual risk of lung ADCA in the general population. © 2008 Wiley‐Liss, Inc.