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A polygenic model for integration of linkage and pathway information

✍ Scribed by J.J.P. Lebrec; I. Nishchenko; H.J. van der Wijk; T.W. Huizinga; H.C. van Houwelingen

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
277 KB
Volume
33
Category
Article
ISSN
0741-0395

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✦ Synopsis

Abstract

We introduce an approximate model for linkage curves which accommodates the polygenic structure of complex diseases and accounts for the simultaneous action of closely located genes. The model is extended so that information on biological pathways can be integrated. Using data on rheumatoid arthritis, we describe some of the many applications which the model allows: it can be used to test for residual linkage in the presence of already established loci, to derive a global test for linkage, to test for the relevance of a gene list in terms of linkage and to help in candidate gene prioritization by integration of gene‐pathway annotation data. Genet. Epidemiol. 2009. Β© 2008 Wiley‐Liss, Inc.

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