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A Poly(acrylic acid)-block-Poly(L-glutamic acid) Diblock Copolymer with Improved Cell Adhesion for Surface Modification

✍ Scribed by Bin Cao; Shifeng Yan; Kunxi Zhang; Zhijiang Song; Tian Cao; Xuesi Chen; Lei Cui; Jingbo Yin

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 580 KB
Volume: 11
Category: Article
ISSN: 1616-5187
DOI: 10.1002/mabi.201100010

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✦ Synopsis

Abstract

A novel PAA__‐b‐PLGA diblock copolymer is synthesized and characterized that has excellent cell adhesion and biocompatibility. Fluorescent DiO labeling is used to monitor the attachment and growth of hASCs on the film surface, and cell proliferation over time is studied. Results show that PLLA modified by a CS/PAA‐b‐PLGA multilayer film can promote the attachment of human hASCs and provide an advantageous environment for their proliferation. The multilayer film presents excellent biocompatibility and cell adhesive properties, which will provide a new choice for improving the cell attachment in surface modification for tissue engineering. Hydroxyl, carboxyl and amine groups in the CS/PAA‐b‐__PLGA multilayer film may be combined with drugs and growth factors for therapy and differentiation. magnified image

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