A polarographic and voltammetric study of some primary, secondary and tertiary thioamides of pharmaceutical importance

✍ Scribed by Ian E. Davidson; W.Franklin Smyth

• Publisher: Elsevier Science
• Year: 1983
• Tongue: English
• Weight: 715 KB
• Volume: 147
• Category: Article
• ISSN: 0003-2670
• DOI: 10.1016/0003-2670(83)80072-5

✦ Synopsis

The d.c. polarographic, and cyclic and cathodic stripping voltammetric behaviour of some primary, secondary and tertiary thioamides based on tetrahydroquinoline, IS described. Catalytic reduction occurs in all cases; the primary and secondary thioamides undergo anodic oxidation and cathodic stripping, with the formation of mercury(I1) sulphide. Tertiary thioamides are not amenable to anodic electrolysis/stripping. Mechanisms for these oxidation and reduction processes are postulated. Differential pulse polarography has a limit of detection of 5 X lo-' M. Cathodic stripping voltammetry can be applied with a detection limit of 2 x 10d M.