A Plastid Mutation in Tobacco (Nicotiana tabacum L.) is Associated with Reduced Levels of Mitochondrial Cytochrome C Oxidase and Glycine Decarboxylase

m.6267G>A: a recurrent mutation in the h

m.6267G>A: a recurrent mutation in the human mitochondrial DNA that reduces cytochrome c oxidase activity and is associated with tumors

✍ M. Esther Gallardo; Raquel Moreno-Loshuertos; Celia López; Mercedes Casqueiro; J 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 259 KB

Complete sequencing of the mitochondrial genome of 13 cell lines derived from a variety of human cancers revealed nine novel mitochondrial DNA (mtDNA) variations. One of them, m.6267G>A, is a recurrent mutation that introduces the Ala122Thr substitution in the mitochondrially encoded cytochrome c ox