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A Placebo-Controlled Trial of Pioglitazone in Subjects with Nonalcoholic Steatohepatitis

✍ Scribed by Belfort, Renata; Harrison, Stephen A.; Brown, Kenneth; Darland, Celia; Finch, Joan; Hardies, Jean; Balas, Bogdan; Gastaldelli, Amalia; Tio, Fermin; Pulcini, Joseph; Berria, Rachele; Ma, Jennie Z.; Dwivedi, Sunil; Havranek, Russell; Fincke, Chris; DeFronzo, Ralph; Bannayan, George A.; Schenker, Steven; Cusi, Kenneth

Book ID
121079691
Publisher
Massachusetts Medical Society
Year
2006
Tongue
English
Weight
291 KB
Volume
355
Category
Article
ISSN
0096-6762

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In nonalcoholic steatohepatitis (NASH), the extent of hepatocyte apoptosis correlates with disease severity. Reducing hepatocyte apoptosis with the selective caspase inhibitor GS-9450 has a potential for altering the course of the liver disease. In this phase 2, double-blind study, 124 subjects with