Generation of loss of heterozygosity and
β
Masamitsu Honma
π
Article
π
2005
π
John Wiley and Sons
π
English
β 390 KB
π 1 views
## Abstract Loss of heterozygosity (LOH) is a critical event in the development of human cancers. LOH is thought to result from either a large deletion or recombination between homologous alleles during repair of DNA doubleβstrand breaks (DSBs). These types of genetic alterations produce mutations