A Pilot Study of Leukocytapheresis Efficacy With 1.5 Liter Blood Processing Volume in Patients With Ulcerative Colitis
โ Scribed by Masaaki Shimada; Hiroaki Iwase; Tomoyuki Tsuzuki; Noboru Hirashima; Kyoko Kobayashi; Yusuke Hibino; Hisanori Watanabe; Nobumitsu Ryuge; Takafumi Ando; Hidemi Goto; Yuhki Yagi; Tomoyuki Tsujikawa; Akira Andoh
- Book ID
- 111334074
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 175 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1091-6660
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๐ SIMILAR VOLUMES
## Abstract **Background**: Leukocytapheresis (LCAP) is used as an adjunct therapy for patients with active ulcerative colitis (UC). Although, LCAP is routinely performed at 3,000 mL per session, we were interested to see that if this can be replaced with bodyweight (BW) adjusted volume. **Methods*
Background: During active ulcerative colitis (UC), vast numbers of granulocytes, monocytes/macrophages (GM) infiltrate the mucosal tissue and can potentially exacerbate inflammation and injury. Accordingly, we were interested to see if selective depletion of GM by adsorption (GMA) impacts mucosal he