## Abstract Safinamide is an α‐aminoamide with both dopaminergic and nondopaminergic mechanisms of action evaluated as an add‐on to dopamine agonist (DA) therapy in early‐stage PD. In this 24‐week, double‐blind study, patients with early PD receiving a stable dose of a single DA were randomized to
A pilot randomized controlled trial of sleep therapy in Parkinson's disease: effect on patients and caregivers
✍ Scribed by Iracema Leroi; Peter Baker; Pam Kehoe; Emily Daniel; E Jane Byrne
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 128 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0885-6230
- DOI
- 10.1002/gps.2472
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Objective
By means of a controlled trial, to investigate the efficacy, tolerability and feasibility of a multi‐component sleep therapy intervention versus basic sleep hygiene education in PD patients with sleep disturbances and their live‐in carers.
Methods
Patient‐carer dyads were randomised to either of the two interventions. Quantitative measures of sleep, psychiatric and overall functioning were administered at baseline and two weeks after the intervention to patients and carers.
Results
Sleep disturbances in the PD patients improved significantly in both the groups. Between group comparisons in both carers and patients revealed no significant differences on any outcome measures. The intervention was found to be well tolerated, feasible and could easily be translated into the clinical setting.
Conclusions
This pilot study makes the case for further, more rigorous study of pragmatic, non‐pharmacological interventions for sleep disturbances in PD. Copyright © 2010 John Wiley & Sons, Ltd.
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