Investigation of 5-FU disposition after
β
Yuko Tsukamoto; Yukio Kato; Masako Ura; Ikuo Horii; Tohru Ishikawa; Hideo Ishits
π
Article
π
2001
π
John Wiley and Sons
π
English
β 274 KB
π 2 views
## Abstract The nonlinear pharmacokinetics of capecitabine, a triple prodrug of 5βFU preferentially activated in tumour tissues, was investigated in human cancer xenograft models. A physiologically based pharmacokinetic (PBPK) model integrating the activation process of capecitabine to 5βFU and 5βF