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A Physicochemical Approach for Predicting the Effectiveness of Peptide-Based Gene Delivery Systems for Use in Plasmid-Based Gene Therapy

✍ Scribed by Duguid, John G.; Li, Cynthia; Shi, Mei; Logan, Mark J.; Alila, Hector; Rolland, Alain; Tomlinson, Eric; Sparrow, James T.; Smith, Louis C.


Book ID
119411824
Publisher
Biophysical Society
Year
1998
Tongue
English
Weight
405 KB
Volume
74
Category
Article
ISSN
0006-3495

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## Abstract ## Background A large‐volume intravenous (i.v.) injection of DNA, i.e. a hydrodynamics‐based transfection procedure, is known to be an efficient and liver‐specific method of __in vivo__ gene delivery. However, little is available on an applicable particle size in the procedure. ## Met