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A phospholipid spin label used as a liposome-associated MRI contrast agent

✍ Scribed by Chris W. M. Grant; Kathryn R. Barber; Eugene Florio; Stephen Karlik

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
417 KB
Volume
5
Category
Article
ISSN
0740-3194

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✦ Synopsis

Given current clinical use of phospholipid hilayer structures (liposomes/vesicles) as nontoxic drug delivery vehicles, we have addressed the possibility of employing the phospholipids themselves as MRI contrast agents. To this end we have synthesized phosphatidylcholine with a nitroxide spin label replacing one methyl residue of the choline headgroup. This material was mixed with natural phosphatidylcholine in mole ratios from 150 to 1: 1 and used to prepare sonicated unilamellar vesicles in saline. Expected structural features of these vesicles were verified by freeze-fracture electron microscopy. Proton TI values of saline were readily decreased to less than 0.3 s by such preparations, yielding a net relaxivity of 0.6 M-' s-'. The approach seems to be a realistic way of firmly associating a contrast agent of minimal toxicity with ordinary liposomes/vesicles in a manner that is not subject to leakage. o 1987 Academic has, Inc.

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