A phorbol ester-nonproliferative variant of Swiss 3T3 cells is deficient in Na+ K+ Cl− cotransport activity

Restoration of responsiveness to phorbol

Restoration of responsiveness to phorbol ester by reconstitution of a functional Na/K/Cl cotransporter in cotransporter-deficient BALB/c 3T3 cells

✍ Yongjun Guo; Thomas G. O'Brien 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 698 KB

Previous studies in this laboratory have implicated the membrane transport protein Na/WCI cotransporter (NKCC1) as an important component of the signaling pathways activated by phorbol esters in BALB/c 3T3 cells. The NKCC1 protein functions as a Na/WCI cotransporter in BALBlc 3T3 cells and many oth