Stereoselective synthesis of the hydroxy
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Akiyoshi Kawai; Osamu Hara; Yasumasa Hamada; Takayuki Shioiri
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Article
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1988
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Elsevier Science
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French
⚖ 222 KB
The hydroxy amino acid moiety of AI-77-B (1) has been prepared as its protected form 2 from the (R)-glyceric acid derivative 3 in an efficiently stereoselective manner through the direct C-acylation using diphenyl phosphorazidate and the hydroxy-directed hydrogenation. Al-77-B having a unique gastr