The heterogeneity of hepatitis C virus (HCV) is due to the continuous and high replication rate, the low fidelity of the RNA-dependent RNA polymerase, and the immune surveillance of the host. Interleukin-12 (IL-12) plays a central role in mounting an effective cellular immune response directed towar
A phase I/II study of recombinant human interleukin-12 in patients with chronic hepatitis C
✍ Scribed by Stefan Zeuzem; Uwe Hopf; Vicente Carreno; Moisés Diago; Mitchell Shiffman; Stefan Grüne; Francis J. Dudley; Ashok Rakhit; Karen Rittweger; Sing Hiem Yap; Raymond S. Koff; Howard C. Thomas
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 114 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The optimal and safer interleukin-2 (IL-2) dose for treatment of chronic hepatitis C virus (HCV) infection has been studied in 33 HCV-RNA positive patients with chronic hepatitis C. Patients were randomly allocated to receive 5 days per week during 12 weeks IL-2 doses of: 0.9 MIU (n = 10), 1.8 MIU (
## Abstract ## BACKGROUND Interleukin‐2 (IL‐2) has activity in metastatic melanoma when given in high doses by the intravenous (IV) route, but its side effects and effectiveness when given in intermediate to high doses by the subcutaneous (SC) route have not been studied adequately. This study sou
Current therapies available for the treatment of chronic hepatitis B are limited in their ability to result in a cure. Clevudine is a new pyrimidine analog with potent anti-hepatitis B virus (HBV) activity in vitro. A multicenter dose-escalation study evaluated clevudine at 10, 50, 100, and 200 mg o
## Abstract Interleukin‐12 and ‐18 (IL‐12 and IL‐18) are known to enhance the cytotoxic T‐lymphocyte response synergistically, but their precise involvement in hepatitis C virus (HCV) infection is not well known, especially for IL‐18. Enzyme‐linked immunosorbent assay (ELISA) was used to study the