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A phase I/II study of high-dose megestrol acetate in the treatment of metastatic breast cancer

✍ Scribed by Howard L. Parnes; Jeffrey S. Abrams; N. Simon Tchekmedyian; Nancy Tait; Joseph Aisner

Publisher
Springer US
Year
1991
Tongue
English
Weight
543 KB
Volume
18
Category
Article
ISSN
0167-6806

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Twenty-three evaluable patients with advanced breast cancer were treated with MPA, 1,400 mg/m2 daily PO for the first 6 months, and 500 mg/m2 daily PO thereafter. The median total dose was 191,400 mg in 88 days, with the maximum dose given to date 522,600 mg in 282 days. Most patients tolerated high