## Background: Diffuse pontine gliomas remain one of the most lethal of pediatric malignancies despite the use of increasingly intensive therapies. we delivered intensive chemotherapy during and following 70.2 gy of hyperfractionated radiation therapy in an attempt to improve survival. ## Procedur
A Phase I/II study of carboplatin combined with hyperfractionated radiotherapy for brainstem gliomas
β Scribed by Jeffrey Allen; Joao Siffert; Bernadine Donahue; Anita Nirenberg; Regina Jakacki; Patricia Robertson; Robert DaRosso; Louisa Thoron; Mark Rosovsky; Richard Pinto
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 75 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
β¦ Synopsis
BACKGROUND.
Brainstem gliomas often respond to radiotherapy but long term disease control is exceptional. The concomitant administration of a chemotherapy agent with radiosensitizing properties such as carboplatin may increase the efficacy of radiotherapy.
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