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A phase I/II study of a 5-day schedule of intravenous topotecan (T) and etoposide (E) regimen in untreated small cell lung cancer (SCLC). A promising combination with potential for oral delivery

✍ Scribed by Clark, P; Sutton, P; Smith, D; Graham, R

Book ID: 118569673
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 142 KB
Volume: 29
Category: Article
ISSN: 0169-5002
DOI: 10.1016/s0169-5002(00)80128-2

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## Abstract ## BACKGROUND Topotecan (9‐dimethylaminomethyl‐10‐hydroxycampthothecin) is a new topoisomerase I inhibitor with promising efficacy in the treatment of patients with small cell lung carcinoma (SCLC). Combination with a topoisomerase II inhibitor may potentate the therapeutic effect of t