Forty-two Women with measurable or evaluable advanced breast cancer who had received neither prior chemotherapy for advanced disease nor any anthracycline-containing regimen as adjuvant were entered in a phase II study of mitoxantrone (Novantrone| dihydroxyanthracenedione). Patients were aged from 3
A phase II trial of paclitaxel (Taxol®) as first line treatment in advanced breast cancer
✍ Scribed by Sandra M. Swain; Susan F. Honig; Mariella C. Tefft; Linda Walton
- Publisher
- Springer US
- Year
- 1995
- Tongue
- English
- Weight
- 467 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0167-6997
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## BACKGROUND. This Phase II multicenter study evaluated the efficacy and toxicity of paclitaxel (200 mg/m 2 by 3-hour infusion) with carboplatin (area under the curve 6 mg/mL per minute) administered every 3 weeks as first-line therapy for women with metastatic breast carcinoma. ## METHODS. Eligi
Mitoxantrone (Novantrone| dihydroxyanthracenedione) is a substituted anthraquinone with a spectrum of activity similar to doxorubicin in experimental tumors. One hundred and seventy three patients with advanced breast cancer and no prior cytotoxic therapy for advanced disease entered a phase II stu