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A phase II study to determine the ability of gefitinib to reverse fluoropyrimidine resistance in metastatic colorectal cancer (the INFORM study)

✍ Scribed by Stebbing, J; Harrison, M; Glynne-Jones, R; Bridgewater, J; Propper, D


Book ID
109999414
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
100 KB
Volume
98
Category
Article
ISSN
0007-0920

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## Abstract Estrogen receptor (ER)‐positive acquired tamoxifen‐resistant (TAM‐R) MCF‐7 breast cancer cell lines exhibit epidermal growth factor receptor (EGFR) expression/signaling and are growth‐inhibited by gefitinib (IRESSA). We examined the effect of gefitinib on ER‐positive TAM‐R and ER‐negati