๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

A phase II study of mitoguazone and vinblastine in advanced transitional cell carcinoma of the urinary tract

โœ Scribed by John T. Barrett; Bruno Orofiamma; Janardan D. Khandekar; Paul P. Carbone; Robert L. Comis; Thomas E. Davis

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
330 KB
Volume
64
Category
Article
ISSN
0008-543X

No coin nor oath required. For personal study only.

โœฆ Synopsis

This is a comparative study to evaluate response rate to mitoguazone (MGBG) and vinblastine (VLB) in 52 evaluable patients with advanced transitional cell carcinoma of the urinary tract. Of 38 patients with measurable disease, two of 18 (11%) on MGBG had partial remission (95% confidence interval: 0.01, 0.35), whereas four of 20 (20%) responded on the VLB arm (95% confidence level: 0.06-0.44). Both responses on the MGBG arm were seen in patients given prior chemotherapy. Side effects of both drugs were significant, with 46% of patients given VLB developing severe or life-threatening hematologic toxicity.

Data indicate that both drugs, as single agents, are probably inferior to cisplatin for control of advanced transitional cell carcinoma of the urinary tract.

๐Ÿ“œ SIMILAR VOLUMES

A study of cyclophosphamide, adriamycin,
A study of cyclophosphamide, adriamycin, cis-platinum, and methotrexate in advanced transitional cell carcinoma of the urinary tract
โœ Dennis L. Citrin; Tom F. Hogan; Tom E. Davis ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 424 KB ๐Ÿ‘ 1 views

Twenty patients with locally advanced and/or metastatic transitional cell cancer of the urinary tract were treated with cyclophosphamide 500 mg/m2, Adriamycin (doxorubicin) 40 mg/m2 and cis-platinum (CDDP) 40 mg/m2 given every three weeks for 2 cycles, alternating with methotrexate 40 mg/m2 weekly f

Microsatellite instability in transition
Microsatellite instability in transitional cell carcinoma of the urinary tract and its relationship to clinicopathological variables and smoking
โœ Toyoaki Uchida; Chunxi Wang; Chieki Wada; Masatsugu Iwamura; Shin Egawa; Ken Kos ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 420 KB ๐Ÿ‘ 2 views

To determine whether microsatellite instability is involved in the development of transitional cell carcinoma (TCC) of the urinary tract, a microsatellite instability assay was carried out using PCR with 9 microsatellite loci. Thirty-eight TCC samples (30 patients with bladder cancer, 5 with renal p