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A phase II study of methylphenidate for the treatment of fatigue

✍ Scribed by Amy Hanna; George Sledge; Mary Lou Mayer; Nasser Hanna; Lawrence Einhorn; Patrick Monahan; Joanne Daggy; Sumeet Bhatia

Publisher
Springer-Verlag
Year
2005
Tongue
English
Weight
100 KB
Volume
14
Category
Article
ISSN
0941-4355

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Difluoromethylornithine (DFMO) is an irreversible enzyme-activated inhibitor of ornithine decarboxylase, a key enzyme in polyamine synthesis. We have screened for potential anti-cancer activity of DFMO using a clonogenic assay, which suggested that melanoma might have sensitivity to this agent. Acco