The National Cancer Institute of Canada (NCIC) Clinical Trials Group has carried out a phase II study of VP-16 100 mg/m 2 daily x 3 and cisplatin 25 mg/m 2 daily x 3 in untreated patients with malignant mesothelioma. Twenty-seven eligible patients were entered on the trial and the majority had pleur
A phase II study evaluating the cisplatin and epirubicin combination in patients with unresectable malignant pleural mesothelioma
โ Scribed by Berghmans, T.; Lafitte, J.J.; Paesmans, M.; Stach, B.; Berchier, M.C.; Wackenier, P.; Lecomte, J.; Collon, T.; Mommen, P.; Sculier, J.P.
- Book ID
- 119319237
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 182 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0169-5002
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## Abstract ## BACKGROUND Malignant pleural mesothelioma (MPM) is increasing rapidly worldwide. Currently, pemetrexed plus cisplatin chemotherapy showed a survival advantage versus cisplatin alone. No impact on patient survival of surgery, radiotherapy, or their combination has been demonstrated.
Cisplatin was given intravenously to 35 evaluable patients with unresectable malignant mesothelioma on Southwest Oncology Group (SWOG) Study 8418. Five patients (14.3%) achieved partial response with median response duration of six months (range 2-12 months); eleven patients (31.4%) had stable disea