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A phase I trial of continuous-infusion cyclophosphamide in refractory cancer patients

โœ Scribed by Joseph P. Eder; Anthony D. Elias; Lois Ayash; Catherine A. Wheeler; Thomas C. Shea; Lowell E. Schnipper; Emil Frei; Karen H. Antman

Publisher
Springer
Year
1991
Tongue
English
Weight
522 KB
Volume
29
Category
Article
ISSN
0344-5704

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Background. Hydroxyurea is an S-phase specific drug. Constant exposure of tumor cells with a low Sphase fraction to the agent may result in improved cell kill. Because of its short half-life, a continuous intravenous infusion may result in better tumor exposure than intake by mouth. The goal of this