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A phase I study to determine the effect of tamoxifen on the pharmacokinetics of a single 250

✍ Scribed by Mireille V. Cantarini; Merran P. Macpherson; Anna L. Marshall; Anna V. Robinson; Christopher J. Bailey

Book ID
105992322
Publisher
Springer
Year
2005
Tongue
English
Weight
256 KB
Volume
56
Category
Article
ISSN
0344-5704

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The effect of tamoxifen on the pharmacok
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The effects of single doses of tamoxifen (TAM; 0.5-5 mg/kg, i.v.) and chronic pretreatment with TAM (0.1-5.0 mg/kg/day, i.p. for 7 consecutive days) on letrozole (0.5 mg/kg, i.v.) pharmacokinetics were evaluated in female Sprague-Dawley rats. The plasma concentration-time profiles of letrozole (0.1-