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A phase I study of tipifarnib combined with conventional induction and consolidation therapy for previously untreated patients with acute myeloid leukemia aged 60 years and over

✍ Scribed by Brandwein, J M; Leber, B F; Howson-Jan, K; Schimmer, A D; Schuh, A C; Gupta, V; Yee, K W L; Wright, J; Moore, M; MacAlpine, K

Book ID
109886713
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
100 KB
Volume
23
Category
Article
ISSN
0887-6924

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## Abstract ## BACKGROUND: The authors conducted a phase 1/2 study of tipifarnib in combination with idarubicin and cytarabine (IA) in 95 patients with previously untreated acute myeloid leukemia (AML) or high‐risk myelodysplastic syndrome. ## METHODS: Induction consisted of idarubicin 12 mg/m^2

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