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A Phase I Study of the Combination of Sorafenib With Temozolomide and Radiation Therapy for the Treatment of Primary and Recurrent High-Grade Gliomas

✍ Scribed by Den, Robert B.; Kamrava, Mitchell; Sheng, Zhi; Werner-Wasik, Maria; Dougherty, Erin; Marinucchi, Michelle; Lawrence, Yaacov R.; Hegarty, Sarah; Hyslop, Terry; Andrews, David W.; Glass, Jon; Friedman, David P.; Green, Michael R.; Camphausen, Kevin; Dicker, Adam P.

Book ID: 122857202
Publisher: Elsevier Science
Year: 2013
Tongue: English
Weight: 539 KB
Volume: 85
Category: Article
ISSN: 0360-3016
DOI: 10.1016/j.ijrobp.2012.04.017

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## Abstract ## BACKGROUND. The prognosis for patients with recurrent high‐grade gliomas is poor and treatment options are limited. Current chemotherapeutic regimens can improve clinical outcomes, but extend survival by only a few months. Temozolomide is a methylating agent that is typically admini