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A phase I study of lapatinib in combination with carboplatin in women with platinum sensitive recurrent ovarian carcinoma

โœ Scribed by Kristopher J. Kimball; T. Michael Numnum; Tyler O. Kirby; William C. Zamboni; Jacob M. Estes; Mack N. Barnes; Daniela E. Matei; Kevin M. Koch; Ronald D. Alvarez


Book ID
113961691
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
194 KB
Volume
111
Category
Article
ISSN
0090-8258

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## Abstract ## BACKGROUND: Aberrant DNA methylation is a hallmark of cancer, and DNA methyltransferase inhibitors have demonstrated clinical efficacy in hematologic malignancies. On the basis of preclinical studies indicating that hypomethylating agents can reverse platinum resistance in ovarian c