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A phase I study of bevacizumab (B) in combination with everolimus (E) and erlotinib (E) in advanced cancer (BEE)

✍ Scribed by Karen E. Bullock; William P. Petros; Islam Younis; Hope E. Uronis; Michael A. Morse; Gerard C. Blobe; S. Yousuf Zafar; Jon P. Gockerman; Joanne J. Lager; Roxanne Truax; Kellen L. Meadows; Leigh A. Howard; Margot M. O’Neill; Gloria Broadwater; Herbert I. Hurwitz; Johanna C. Bendell


Publisher
Springer
Year
2010
Tongue
English
Weight
265 KB
Volume
67
Category
Article
ISSN
0344-5704

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✍ Daniel T. Milton; Gregory J. Riely; Christopher G. Azzoli; Jorge E. Gomez; Rober 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 123 KB 👁 3 views

## Abstract ## BACKGROUND. Preclinical studies have demonstrated that the inhibition of the PI3K/Akt/mTOR pathway restores gefitinib sensitivity in resistant cancer cell lines. A phase 1 study was conducted of the combination of everolimus, an mTOR inhibitor, and gefitinib to determine a daily dos