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A phase I study of Adp53 (INGN 201; ADVEXIN) for patients with platinum- and paclitaxel-resistant epithelial ovarian cancer

โœ Scribed by Judith K Wolf; Diane C Bodurka; Jacalyn B Gano; Michael Deavers; Lois Ramondetta; Pedro T Ramirez; Charles Levenback; David M Gershenson


Book ID
113959374
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
118 KB
Volume
94
Category
Article
ISSN
0090-8258

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## Abstract ## BACKGROUND: Aberrant DNA methylation is a hallmark of cancer, and DNA methyltransferase inhibitors have demonstrated clinical efficacy in hematologic malignancies. On the basis of preclinical studies indicating that hypomethylating agents can reverse platinum resistance in ovarian c