A Phase I clinical and pharmacological study of cis-diamminedichloro(2-methylpyridine) platinum II (AMD473)
β Scribed by Beale, P; Judson, I; O'Donnell, A; Trigo, J; Rees, C; Raynaud, F; Turner, A; Simmons, L; Etterley, L
- Book ID
- 109997529
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 123 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0007-0920
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Eleven patients with osteogenic sarcoma (9), Hodgkin disease (1), and mesenchymal sarcoma (1), were treated with 5βfluorouracil (5βFU) and cisplatin (DDP). Myelosuppression and vomiting of variable degrees occurred in all. No responses were seen.
Thirty-one loading courses of 5-FU and cis-platinum (11) diaminedichloride (CPD) were given to 27 patients with a variety of malignancies. Up to 16 mg/kg/day of 5-FU and 2.5 mg/kg of the platinum were reached with minimal toxicity. Nausea (27/31) and vomiting (23/31) were the most frequent symptoms,