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A phase I and pharmacokinetic trial of KW-2149, a mitomycin C analogue, in patients with solid tumours

✍ Scribed by Dirix, LY; Dumortier, A; Koier, I; Prové, A; Schrijvers, D; De Bruijn, EA; Ardiet, C; Clavel, M; Van Oosterom, AT

Book ID
122544353
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
173 KB
Volume
29
Category
Article
ISSN
0959-8049

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Effects and systemic uptake of the new m
Effects and systemic uptake of the new mitomycin C analogue KW-2149 in beagle dogs after intravesical administration
✍ Sorber, M. ;De Bruijn, E. A. ;Kockx, M. ;Bultinck, J. ;Van Oosterom, A. T. ;Deni 📂 Article 📅 1995 🏛 Springer 🌐 English ⚖ 609 KB

The present study was designed to evaluate the local effects of the new mitomycin C analogue KW-2149 after intravesical instillation, together with its penetration into the systemic circulation in healthy beagle dogs. Two reference dogs were treated with two instillations of mitomycin C (30 mg in 30