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A phase 2 trial of verubulin for recurrent glioblastoma: a prospective study by the brain tumor investigational consortium (BTIC)

✍ Scribed by Chamberlain, Marc C.; Grimm, Sean; Phuphanich, Surasak; Recht, Larry; Zhu, Jay Z.; Kim, Lyndon; Rosenfeld, Steve; Fadul, Camilo E.

Book ID
125366696
Publisher
Springer US
Year
2014
Tongue
English
Weight
380 KB
Volume
118
Category
Article
ISSN
0167-594X

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## Abstract ## BACKGROUND Temozolomide (TMZ) and 1, 3‐bis (2‐chloroethyl)‐1‐nitrosourea (BCNU) are reported to be active agents in anaplastic glioma (AG). TMZ has also been shown to deplete alkyltransferase, a DNA repair enzyme that contributes to nitrosourea resistance. The objective of the curre